Disruption of neonatal Purkinje cell function underlies injury-related learning deficits

Significance Injury to the cerebellum during late fetal and early postnatal life is associated with long-term motor cognitive deficits. It thought that injury at this stage of development results in delayed maturation neural circuitry, causing altered behavior later stages. This study identifies basis locomotor learning deficits using a clinically relevant model neonatal brain injury. By combining fiber-optic-enabled Purkinje cell activity measurement behavior, we provide evidence for changes neuronal responses learning. artificially reducing function stage, observed similarly physiological as those seen Our findings indicate injury-related inhibition developing cells causes dysfunction.